Assay Detail
Binding
CHEMBL4821793
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Inhibition of bacterial ImiS expressed in Escherichia coli BL21 (DE3) using meropenem as substrate incubated for 1 hr by spectrometry analysis
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Dipyridyl-substituted thiosemicarbazone as a potent broad-spectrum inhibitor of metallo-β-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.12 | 7.12 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2203744 | — | — | 2 | 7.12 |
| CHEMBL177837 | BROMOPYRUVATE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2203744 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL2203744 | — | Inhibition | - | % | - | |
| CHEMBL177837 | BROMOPYRUVATE | IC50 | > | 40000.0 | nM | - |