Assay Detail
Binding
CHEMBL4822010
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Displacement of [3H]-methylspiperone from dopamine D4 receptor (unknown origin)
14
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New tetrahydroisoquinoline-based D<sub>3</sub>R ligands with an o-xylenyl linker motif.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.36 | 9.12 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20734 | NEMONAPRIDE | 2.0 | 1 | 9.12 |
| CHEMBL4846574 | — | — | 1 | 7.24 |
| CHEMBL4876260 | — | — | 1 | 7.00 |
| CHEMBL4878587 | — | — | 1 | 6.85 |
| CHEMBL4856161 | — | — | 1 | 6.06 |
| CHEMBL4878121 | — | — | 1 | 6.02 |
| CHEMBL4854512 | — | — | 1 | 6.02 |
| CHEMBL4857166 | — | — | 1 | 5.98 |
| CHEMBL4867331 | — | — | 1 | 5.97 |
| CHEMBL4862839 | — | — | 1 | 5.94 |
| CHEMBL4876546 | — | — | 1 | 5.55 |
| CHEMBL4877460 | — | — | 1 | 5.47 |
| CHEMBL4863748 | — | — | 1 | 5.41 |
| CHEMBL4854935 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20734 | NEMONAPRIDE | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL4846574 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL4876260 | — | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL4878587 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL4856161 | — | Ki | = | 880.0 | nM | 6.06 |
| CHEMBL4878121 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL4854512 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL4857166 | — | Ki | = | 1040.0 | nM | 5.98 |
| CHEMBL4867331 | — | Ki | = | 1070.0 | nM | 5.97 |
| CHEMBL4862839 | — | Ki | = | 1150.0 | nM | 5.94 |
| CHEMBL4876546 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL4877460 | — | Ki | = | 3360.0 | nM | 5.47 |
| CHEMBL4863748 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL4854935 | — | Inhibition | < | 10.0 | % | - |