Assay Detail
Binding
CHEMBL4822041
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Inhibition of APN (unknown origin) using A-AMC as substrate
12
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Investigating the phosphinic acid tripeptide mimetic DG013A as a tool compound inhibitor of the M1-aminopeptidase ERAP1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.68 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4854733 | — | — | 2 | 8.82 |
| CHEMBL4877339 | — | — | 2 | 8.64 |
| CHEMBL3416733 | — | — | 2 | 8.44 |
| CHEMBL4853049 | — | — | 2 | 8.07 |
| CHEMBL4863168 | — | — | 2 | 6.65 |
| CHEMBL4872604 | — | — | 2 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4854733 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4854733 | — | IC50 | = | 1.549 | nM | 8.81 |
| CHEMBL4877339 | — | IC50 | = | 2.291 | nM | 8.64 |
| CHEMBL4877339 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL3416733 | — | IC50 | = | 3.631 | nM | 8.44 |
| CHEMBL3416733 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4853049 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL4853049 | — | IC50 | = | 8.71 | nM | 8.06 |
| CHEMBL4863168 | — | IC50 | = | 223.87 | nM | 6.65 |
| CHEMBL4863168 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4872604 | — | IC50 | = | 3388.44 | nM | 5.47 |
| CHEMBL4872604 | — | IC50 | = | 3400.0 | nM | 5.47 |