Assay Detail
Binding
CHEMBL4822089
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Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated with enzyme for 5 mins followed by substrate addition by colorimetric analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel 1,2,4-triazine-quinoline hybrids: The privileged scaffolds as potent multi-target inhibitors of LPS-induced inflammatory response via dual COX-2 and 15-LOX inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.98 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 7.35 |
| CHEMBL4867950 | — | — | 1 | 7.33 |
| CHEMBL4847404 | — | — | 1 | 7.27 |
| CHEMBL4856646 | — | — | 1 | 7.22 |
| CHEMBL4872636 | — | — | 1 | 7.19 |
| CHEMBL4861765 | — | — | 1 | 7.17 |
| CHEMBL4853361 | — | — | 1 | 7.14 |
| CHEMBL4876293 | — | — | 1 | 7.10 |
| CHEMBL4876862 | — | — | 1 | 7.07 |
| CHEMBL4869763 | — | — | 1 | 7.01 |
| CHEMBL4862389 | — | — | 1 | 6.96 |
| CHEMBL4852008 | — | — | 1 | 6.92 |
| CHEMBL4876637 | — | — | 1 | 6.80 |
| CHEMBL4857790 | — | — | 1 | 6.55 |
| CHEMBL4862415 | — | — | 1 | 6.50 |
| CHEMBL1034 | DICLOFENAC SODIUM | 4.0 | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4867950 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4847404 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4856646 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4872636 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4861765 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL4853361 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4876293 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4876862 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4869763 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL4862389 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4852008 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4876637 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4857790 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4862415 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1034 | DICLOFENAC SODIUM | IC50 | = | 840.0 | nM | 6.08 |