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Assay Detail

CHEMBL4822091

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of soybean 15-LOX using arachidonic acid or linolenic acid as substrate in presence of hydrogen peroxide incubated for 5 mins by colorimetric analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Glycine max
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Novel 1,2,4-triazine-quinoline hybrids: The privileged scaffolds as potent multi-target inhibitors of LPS-induced inflammatory response via dual COX-2 and 15-LOX inhibition.
Ghanim AM, Rezq S, Ibrahim TS, Romero DG, Kothayer H.
Eur J Med Chem (2021) 219 : 113457 -113457
PubMed 33892270 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.63 5.74

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4867950 1 5.74
CHEMBL4876637 1 5.73
CHEMBL4861765 1 5.71
CHEMBL4876862 1 5.71
CHEMBL4872636 1 5.69
CHEMBL4847404 1 5.67
CHEMBL4876293 1 5.67
CHEMBL4869763 1 5.66
CHEMBL4853361 1 5.63
CHEMBL4862389 1 5.62
CHEMBL4856646 1 5.59
CHEMBL4857790 1 5.58
CHEMBL50 QUERCETIN 3.0 1 5.48
CHEMBL4852008 1 5.47
CHEMBL4862415 1 5.46

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4867950 IC50 = 1810.0 nM 5.74
CHEMBL4876637 IC50 = 1860.0 nM 5.73
CHEMBL4861765 IC50 = 1970.0 nM 5.71
CHEMBL4876862 IC50 = 1970.0 nM 5.71
CHEMBL4872636 IC50 = 2060.0 nM 5.69
CHEMBL4847404 IC50 = 2120.0 nM 5.67
CHEMBL4876293 IC50 = 2130.0 nM 5.67
CHEMBL4869763 IC50 = 2180.0 nM 5.66
CHEMBL4853361 IC50 = 2320.0 nM 5.63
CHEMBL4862389 IC50 = 2380.0 nM 5.62
CHEMBL4856646 IC50 = 2570.0 nM 5.59
CHEMBL4857790 IC50 = 2660.0 nM 5.58
CHEMBL50 QUERCETIN IC50 = 3340.0 nM 5.48
CHEMBL4852008 IC50 = 3390.0 nM 5.47
CHEMBL4862415 IC50 = 3490.0 nM 5.46