Assay Detail
Functional
CHEMBL4822563
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Cytotoxicity against human UCH2 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | UCH2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and evaluation of 1,2,3-dithiazoles and fused 1,2,4-dithiazines as anti-cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 4.46 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4852262 | — | — | 1 | 4.85 |
| CHEMBL4867210 | — | — | 1 | 4.77 |
| CHEMBL1724945 | — | — | 1 | 4.75 |
| CHEMBL4869386 | — | — | 1 | 4.72 |
| CHEMBL4857238 | — | — | 1 | 4.68 |
| CHEMBL4868288 | — | — | 1 | 4.66 |
| CHEMBL1712016 | — | — | 1 | 4.66 |
| CHEMBL4847778 | — | — | 1 | 4.64 |
| CHEMBL4864771 | — | — | 1 | 4.52 |
| CHEMBL4866456 | — | — | 1 | 4.51 |
| CHEMBL4865066 | — | — | 1 | 4.48 |
| CHEMBL4854557 | — | — | 1 | 4.47 |
| CHEMBL4858827 | — | — | 1 | 4.44 |
| CHEMBL4849793 | — | — | 1 | 4.43 |
| CHEMBL4859742 | — | — | 1 | 4.42 |
| CHEMBL4872068 | — | — | 1 | 4.42 |
| CHEMBL4867768 | — | — | 1 | 4.37 |
| CHEMBL4873897 | — | — | 1 | 4.32 |
| CHEMBL1708334 | — | — | 1 | 4.29 |
| CHEMBL4874940 | — | — | 1 | 4.28 |
| CHEMBL4848106 | — | — | 1 | 4.23 |
| CHEMBL4874781 | — | — | 1 | 4.19 |
| CHEMBL4849238 | — | — | 1 | 4.17 |
| CHEMBL4876624 | — | — | 1 | 4.07 |
| CHEMBL4856544 | — | — | 1 | 4.06 |
| CHEMBL4847421 | — | — | 1 | - |
| CHEMBL4871448 | — | — | 1 | - |
| CHEMBL4869718 | — | — | 1 | - |
| CHEMBL4864075 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4852262 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4867210 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1724945 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4869386 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4857238 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4868288 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL1712016 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4847778 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL4864771 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4866456 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL4865066 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL4854557 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL4858827 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL4849793 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL4859742 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL4872068 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL4867768 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL4873897 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL1708334 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL4874940 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL4848106 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL4874781 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL4849238 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL4876624 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL4856544 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL4847421 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4871448 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4869718 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4864075 | — | IC50 | > | 100000.0 | nM | - |