Assay Detail
Functional
CHEMBL4822730
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Anti-necroptotic activity against TNFalph/Z-VAD-FMK-induced human U-937 cells assessed as cell viability measured after 19 to 21 hrs by CellTiter-Glo luminescent cell viability assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Enantiomeric profiling of a chiral benzothiazole necroptosis inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.20 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4521353 | — | — | 1 | 8.40 |
| CHEMBL3785703 | — | — | 1 | 8.00 |
| CHEMBL4864631 | — | — | 1 | - |
| CHEMBL4442060 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4521353 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3785703 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4864631 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4442060 | — | IC50 | > | 10000.0 | nM | - |