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Assay Detail

CHEMBL4822845

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability measured after 48 hrs by AlamarBlue assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HT-29
Confidence 1 — Organism
Curated By Autocuration

Target

HT-29 (CHEMBL384)
Type CELL-LINE
Organism Homo sapiens

Publication

Exploiting the HSP60/10 chaperonin system as a chemotherapeutic target for colorectal cancer.
Ray AM, Salim N, Stevens M, Chitre S, Abdeen S, Washburn A, Sivinski J, O'Hagan HM, Chapman E, Johnson SM.
Bioorg Med Chem (2021) 40 : 116129 -116129
PubMed 33971488 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 24 4.82 5.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4876581 1 5.72
CHEMBL4855678 1 5.64
CHEMBL4281358 1 5.03
CHEMBL1389174 1 4.96
CHEMBL4281802 1 4.96
CHEMBL3908434 1 4.89
CHEMBL4874757 1 4.85
CHEMBL3983712 1 4.82
CHEMBL4858877 1 4.82
CHEMBL3903813 1 4.80
CHEMBL4858760 1 4.80
CHEMBL3978830 1 4.80
CHEMBL3979736 1 4.77
CHEMBL3913878 1 4.77
CHEMBL3970551 1 4.72
CHEMBL4293874 1 4.70
CHEMBL4161487 1 4.68
CHEMBL4277733 1 4.68
CHEMBL3115908 1 4.68
CHEMBL3943318 1 4.62
CHEMBL4280410 1 4.52
CHEMBL3934460 1 4.51
CHEMBL4162794 1 4.48
CHEMBL3947198 1 4.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4876581 EC50 = 1900.0 nM 5.72
CHEMBL4855678 EC50 = 2300.0 nM 5.64
CHEMBL4281358 EC50 = 9300.0 nM 5.03
CHEMBL1389174 EC50 = 11000.0 nM 4.96
CHEMBL4281802 EC50 = 11000.0 nM 4.96
CHEMBL3908434 EC50 = 13000.0 nM 4.89
CHEMBL4874757 EC50 = 14000.0 nM 4.85
CHEMBL3983712 EC50 = 15000.0 nM 4.82
CHEMBL4858877 EC50 = 15000.0 nM 4.82
CHEMBL3903813 EC50 = 16000.0 nM 4.80
CHEMBL4858760 EC50 = 16000.0 nM 4.80
CHEMBL3978830 EC50 = 16000.0 nM 4.80
CHEMBL3979736 EC50 = 17000.0 nM 4.77
CHEMBL3913878 EC50 = 17000.0 nM 4.77
CHEMBL3970551 EC50 = 19000.0 nM 4.72
CHEMBL4293874 EC50 = 20000.0 nM 4.70
CHEMBL4161487 EC50 = 21000.0 nM 4.68
CHEMBL4277733 EC50 = 21000.0 nM 4.68
CHEMBL3115908 EC50 = 21000.0 nM 4.68
CHEMBL3943318 EC50 = 24000.0 nM 4.62
CHEMBL4280410 EC50 = 30000.0 nM 4.52
CHEMBL3934460 EC50 = 31000.0 nM 4.51
CHEMBL4162794 EC50 = 33000.0 nM 4.48
CHEMBL3947198 EC50 = 40000.0 nM 4.40