Assay Detail
Functional
CHEMBL4822880
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human TMD8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | TMD8 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of imidazopyridazine derivatives containing isoquinoline group as potent MNK1/2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.56 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4878199 | — | — | 1 | 6.41 |
| CHEMBL4872637 | — | — | 1 | 5.69 |
| CHEMBL4862651 | — | — | 1 | 5.68 |
| CHEMBL4211649 | TINODASERTIB | 2.0 | 1 | 5.67 |
| CHEMBL4852274 | — | — | 1 | 5.64 |
| CHEMBL4862069 | — | — | 1 | 5.62 |
| CHEMBL4865426 | — | — | 1 | 5.59 |
| CHEMBL4879113 | — | — | 1 | 5.51 |
| CHEMBL4857770 | — | — | 1 | 5.46 |
| CHEMBL4858035 | — | — | 1 | 5.40 |
| CHEMBL4864827 | — | — | 1 | 5.37 |
| CHEMBL4865340 | — | — | 1 | 5.18 |
| CHEMBL4857509 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4878199 | — | IC50 | = | 389.6 | nM | 6.41 |
| CHEMBL4872637 | — | IC50 | = | 2063.0 | nM | 5.69 |
| CHEMBL4862651 | — | IC50 | = | 2085.0 | nM | 5.68 |
| CHEMBL4211649 | TINODASERTIB | IC50 | = | 2138.0 | nM | 5.67 |
| CHEMBL4852274 | — | IC50 | = | 2301.0 | nM | 5.64 |
| CHEMBL4862069 | — | IC50 | = | 2419.0 | nM | 5.62 |
| CHEMBL4865426 | — | IC50 | = | 2555.0 | nM | 5.59 |
| CHEMBL4879113 | — | IC50 | = | 3096.0 | nM | 5.51 |
| CHEMBL4857770 | — | IC50 | = | 3465.0 | nM | 5.46 |
| CHEMBL4858035 | — | IC50 | = | 4010.0 | nM | 5.40 |
| CHEMBL4864827 | — | IC50 | = | 4261.0 | nM | 5.37 |
| CHEMBL4865340 | — | IC50 | = | 6641.0 | nM | 5.18 |
| CHEMBL4857509 | — | IC50 | = | 7568.0 | nM | 5.12 |