Assay Detail
Functional
CHEMBL4822915
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Huprine Y - Tryptophan heterodimers with potential implication to Alzheimer's disease treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.89 | 5.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4874244 | — | — | 1 | 5.32 |
| CHEMBL4556281 | — | — | 1 | 5.31 |
| CHEMBL4856400 | — | — | 1 | 5.25 |
| CHEMBL4878434 | — | — | 1 | 4.91 |
| CHEMBL4850590 | — | — | 1 | 4.83 |
| CHEMBL536047 | — | — | 1 | 4.80 |
| CHEMBL292314 | — | — | 1 | 4.37 |
| CHEMBL1256415 | — | — | 1 | 4.35 |
| CHEMBL95 | TACRINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4874244 | — | IC50 | = | 4770.0 | nM | 5.32 |
| CHEMBL4556281 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4856400 | — | IC50 | = | 5630.0 | nM | 5.25 |
| CHEMBL4878434 | — | IC50 | = | 12270.0 | nM | 4.91 |
| CHEMBL4850590 | — | IC50 | = | 14910.0 | nM | 4.83 |
| CHEMBL536047 | — | IC50 | = | 15870.0 | nM | 4.80 |
| CHEMBL292314 | — | IC50 | = | 43200.0 | nM | 4.37 |
| CHEMBL1256415 | — | IC50 | = | 44370.0 | nM | 4.35 |
| CHEMBL95 | TACRINE | IC50 | = | 168470.0 | nM | - |