Assay Detail
Binding
CHEMBL4822941
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Inhibition of human GSK-3beta incubated with substrate in presence of ATP measured by serial dilution assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A novel GSK-3 inhibitor binds to GSK-3β via a reversible, time and Cys-199-dependent mechanism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.33 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50894 | ALSTERPAULLONE | — | 1 | 8.19 |
| CHEMBL4861930 | — | — | 1 | 6.43 |
| CHEMBL3545157 | TIDEGLUSIB | 2.0 | 1 | 5.75 |
| CHEMBL471474 | HYPOTHEMYCIN | — | 1 | 4.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50894 | ALSTERPAULLONE | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL4861930 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3545157 | TIDEGLUSIB | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL471474 | HYPOTHEMYCIN | IC50 | = | 11300.0 | nM | 4.95 |