Assay Detail
Functional
CHEMBL4823019
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Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 72 hrs by CellTiter-Glo assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of bifunctional PTP4A3 phosphatase inhibitors activating the ER stress pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 4.76 | 5.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4852178 | — | — | 1 | 5.07 |
| CHEMBL4856668 | — | — | 1 | 4.94 |
| CHEMBL4862502 | — | — | 1 | 4.93 |
| CHEMBL4862721 | — | — | 1 | 4.50 |
| CHEMBL4445621 | — | — | 1 | 4.37 |
| CHEMBL4872053 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4852178 | — | EC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL4856668 | — | EC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL4862502 | — | EC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL4862721 | — | EC50 | = | 31600.0 | nM | 4.50 |
| CHEMBL4445621 | — | EC50 | = | 42700.0 | nM | 4.37 |
| CHEMBL4872053 | — | EC50 | > | 50000.0 | nM | - |