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Assay Detail

CHEMBL4823052

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antifungal activity against Candida albicans CAAL93 assessed as reduction in fungal growth
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Candida albicans
Confidence 1 — Organism
Curated By Autocuration

Target

Candida albicans (CHEMBL366)
Type ORGANISM
Organism Candida albicans

Publication

Anti-protozoal and anti-fungal evaluation of 3,5-disubstituted 1,2-dioxolanes.
Pinet A, Cojean S, Nguyen LT, Vásquez-Ocmín P, Maciuk A, Loiseau PM, Le Pape P, Figadère B, Ferrié L.
Bioorg Med Chem Lett (2021) 47 : 128196 -128196
PubMed 34116159 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 5.01 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL106 FLUCONAZOLE 4.0 1 6.52
CHEMBL4847944 1 4.60
CHEMBL4856099 1 4.48
CHEMBL4857972 1 4.45
CHEMBL4868886 1 -
CHEMBL4859589 1 -
CHEMBL4876043 1 -
CHEMBL4856106 1 -
CHEMBL4855756 1 -
CHEMBL4859795 1 -
CHEMBL4877211 1 -
CHEMBL4862084 1 -
CHEMBL4864214 1 -
CHEMBL4876995 1 -
CHEMBL4874504 1 -
CHEMBL4865110 1 -
CHEMBL4874963 1 -
CHEMBL4847542 1 -
CHEMBL4866159 1 -
CHEMBL4859408 1 -
CHEMBL4876410 1 -
CHEMBL4855721 1 -
CHEMBL4867271 1 -
CHEMBL4865003 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL106 FLUCONAZOLE IC50 = 300.0 nM 6.52
CHEMBL4847944 IC50 = 25240.0 nM 4.60
CHEMBL4856099 IC50 = 33390.0 nM 4.48
CHEMBL4857972 IC50 = 35730.0 nM 4.45
CHEMBL4868886 IC50 > 100000.0 nM -
CHEMBL4859589 IC50 > 100000.0 nM -
CHEMBL4876043 IC50 > 100000.0 nM -
CHEMBL4856106 IC50 > 100000.0 nM -
CHEMBL4855756 IC50 > 100000.0 nM -
CHEMBL4859795 IC50 > 100000.0 nM -
CHEMBL4877211 IC50 > 100000.0 nM -
CHEMBL4862084 IC50 > 100000.0 nM -
CHEMBL4864214 IC50 > 100000.0 nM -
CHEMBL4876995 IC50 > 100000.0 nM -
CHEMBL4874504 IC50 > 100000.0 nM -
CHEMBL4865110 IC50 > 100000.0 nM -
CHEMBL4874963 IC50 > 100000.0 nM -
CHEMBL4847542 IC50 > 100000.0 nM -
CHEMBL4866159 IC50 > 100000.0 nM -
CHEMBL4859408 IC50 > 100000.0 nM -
CHEMBL4876410 IC50 > 100000.0 nM -
CHEMBL4855721 IC50 > 100000.0 nM -
CHEMBL4867271 IC50 > 100000.0 nM -
CHEMBL4865003 IC50 > 100000.0 nM -