Assay Detail
Functional
CHEMBL4823211
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Antiproliferation activity against human A549 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel ligustrazine-chalcone derivatives as potential anti-triple negative breast cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.09 | 5.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4870169 | — | — | 1 | 5.61 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.60 |
| CHEMBL4868545 | — | — | 1 | 5.38 |
| CHEMBL4853299 | — | — | 1 | 5.35 |
| CHEMBL4852169 | — | — | 1 | 5.30 |
| CHEMBL4866892 | — | — | 1 | 5.14 |
| CHEMBL4848384 | — | — | 1 | 5.13 |
| CHEMBL4877619 | — | — | 1 | 5.13 |
| CHEMBL4862379 | — | — | 1 | 5.07 |
| CHEMBL4875204 | — | — | 1 | 5.00 |
| CHEMBL4858671 | — | — | 1 | 4.99 |
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 4.82 |
| CHEMBL303697 | LIGUSTRAZINE | — | 1 | 4.44 |
| CHEMBL129795 | ISOLIQUIRITIGENIN | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4870169 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL4868545 | — | IC50 | = | 4150.0 | nM | 5.38 |
| CHEMBL4853299 | — | IC50 | = | 4480.0 | nM | 5.35 |
| CHEMBL4852169 | — | IC50 | = | 5060.0 | nM | 5.30 |
| CHEMBL4866892 | — | IC50 | = | 7270.0 | nM | 5.14 |
| CHEMBL4848384 | — | IC50 | = | 7390.0 | nM | 5.13 |
| CHEMBL4877619 | — | IC50 | = | 7350.0 | nM | 5.13 |
| CHEMBL4862379 | — | IC50 | = | 8470.0 | nM | 5.07 |
| CHEMBL4875204 | — | IC50 | = | 9990.0 | nM | 5.00 |
| CHEMBL4858671 | — | IC50 | = | 10180.0 | nM | 4.99 |
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 15230.0 | nM | 4.82 |
| CHEMBL303697 | LIGUSTRAZINE | IC50 | = | 36460.0 | nM | 4.44 |
| CHEMBL129795 | ISOLIQUIRITIGENIN | IC50 | = | 52580.0 | nM | 4.28 |