Assay Detail
Binding
CHEMBL4823336
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Inhibition of HDAC in human A2780 cells using Boc-Lys (acetyl)-AMC as substrate preincubated for 18 hrs followed by susbtrate addition and measured after 3 hrs by fluorescence microplate reader assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synergistic induction of apoptosis in resistant head and neck carcinoma and leukemia by alkoxyamide-based histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.95 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4875953 | — | — | 1 | 6.72 |
| CHEMBL4870868 | — | — | 1 | 6.60 |
| CHEMBL4876405 | — | — | 1 | 6.46 |
| CHEMBL4866536 | — | — | 1 | 6.32 |
| CHEMBL4876613 | — | — | 1 | 6.22 |
| CHEMBL4849008 | — | — | 1 | 6.19 |
| CHEMBL4850081 | — | — | 1 | 6.17 |
| CHEMBL4863947 | — | — | 1 | 6.15 |
| CHEMBL4863503 | — | — | 1 | 6.13 |
| CHEMBL4848096 | — | — | 1 | 6.07 |
| CHEMBL4846633 | — | — | 1 | 5.87 |
| CHEMBL4856574 | — | — | 1 | 5.80 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.78 |
| CHEMBL4872129 | — | — | 1 | 5.77 |
| CHEMBL4874486 | — | — | 1 | 5.62 |
| CHEMBL4856406 | — | — | 1 | 5.57 |
| CHEMBL4866591 | — | — | 1 | 5.43 |
| CHEMBL4878601 | — | — | 1 | 5.12 |
| CHEMBL4873971 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4875953 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4870868 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4876405 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4866536 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4876613 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4849008 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4850081 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL4863947 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL4863503 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4848096 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL4846633 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL4856574 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL4872129 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL4874486 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL4856406 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4866591 | — | IC50 | = | 3710.0 | nM | 5.43 |
| CHEMBL4878601 | — | IC50 | = | 7680.0 | nM | 5.12 |
| CHEMBL4873971 | — | IC50 | = | 9080.0 | nM | 5.04 |