Assay Detail
Binding
CHEMBL4823337
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Inhibition of HDAC in human CAL-27 cells using Boc-Lys (acetyl)-AMC as substrate preincubated for 18 hrs followed by susbtrate addition and measured after 3 hrs by fluorescence microplate reader assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CAL-27 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synergistic induction of apoptosis in resistant head and neck carcinoma and leukemia by alkoxyamide-based histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.09 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4876405 | — | — | 1 | 7.00 |
| CHEMBL4850081 | — | — | 1 | 6.92 |
| CHEMBL4866536 | — | — | 1 | 6.75 |
| CHEMBL4876613 | — | — | 1 | 6.40 |
| CHEMBL4863947 | — | — | 1 | 6.37 |
| CHEMBL4848096 | — | — | 1 | 6.35 |
| CHEMBL4849008 | — | — | 1 | 6.34 |
| CHEMBL4863503 | — | — | 1 | 6.32 |
| CHEMBL4875953 | — | — | 1 | 6.31 |
| CHEMBL4846633 | — | — | 1 | 6.09 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.06 |
| CHEMBL4870868 | — | — | 1 | 5.82 |
| CHEMBL4866591 | — | — | 1 | 5.76 |
| CHEMBL4874486 | — | — | 1 | 5.72 |
| CHEMBL4872129 | — | — | 1 | 5.70 |
| CHEMBL4856574 | — | — | 1 | 5.65 |
| CHEMBL4856406 | — | — | 1 | 5.50 |
| CHEMBL4873971 | — | — | 1 | 5.38 |
| CHEMBL4878601 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4876405 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4850081 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4866536 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4876613 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4863947 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4848096 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4849008 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4863503 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4875953 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4846633 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL4870868 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4866591 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL4874486 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL4872129 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL4856574 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL4856406 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL4873971 | — | IC50 | = | 4170.0 | nM | 5.38 |
| CHEMBL4878601 | — | IC50 | = | 5970.0 | nM | 5.22 |