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Assay Detail

CHEMBL4823339

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Functional
Antiproliferative activity against human CAL-27 cells assessed as reduction in cell viability after 72 hrs by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CAL-27
Confidence 1 — Organism
Curated By Autocuration

Target

CAL-27 (CHEMBL1075408)
Type CELL-LINE
Organism Homo sapiens

Publication

Synergistic induction of apoptosis in resistant head and neck carcinoma and leukemia by alkoxyamide-based histone deacetylase inhibitors.
Alves Avelar LA, Schrenk C, Sönnichsen M, Hamacher A, Hansen FK, Schliehe-Diecks J, Borkhardt A, Bhatia S, Kassack MU, Kurz T.
Eur J Med Chem (2021) 211 : 113095 -113095
PubMed 33360560 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.77 6.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4876405 1 6.75
CHEMBL4866536 1 6.60
CHEMBL4850081 1 6.52
CHEMBL4856574 1 6.30
CHEMBL4872129 1 6.11
CHEMBL4875953 1 6.10
CHEMBL4849008 1 6.00
CHEMBL4863503 1 5.92
CHEMBL4848096 1 5.89
CHEMBL4846633 1 5.77
CHEMBL4863947 1 5.75
CHEMBL98 VORINOSTAT 4.0 1 5.70
CHEMBL4870868 1 5.67
CHEMBL4866591 1 5.45
CHEMBL4874486 1 5.38
CHEMBL4876613 1 5.37
CHEMBL4856406 1 5.20
CHEMBL4878601 1 4.92
CHEMBL4873971 1 4.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4876405 IC50 = 180.0 nM 6.75
CHEMBL4866536 IC50 = 250.0 nM 6.60
CHEMBL4850081 IC50 = 300.0 nM 6.52
CHEMBL4856574 IC50 = 500.0 nM 6.30
CHEMBL4872129 IC50 = 780.0 nM 6.11
CHEMBL4875953 IC50 = 800.0 nM 6.10
CHEMBL4849008 IC50 = 1000.0 nM 6.00
CHEMBL4863503 IC50 = 1200.0 nM 5.92
CHEMBL4848096 IC50 = 1300.0 nM 5.89
CHEMBL4846633 IC50 = 1700.0 nM 5.77
CHEMBL4863947 IC50 = 1800.0 nM 5.75
CHEMBL98 VORINOSTAT IC50 = 1980.0 nM 5.70
CHEMBL4870868 IC50 = 2120.0 nM 5.67
CHEMBL4866591 IC50 = 3570.0 nM 5.45
CHEMBL4874486 IC50 = 4200.0 nM 5.38
CHEMBL4876613 IC50 = 4300.0 nM 5.37
CHEMBL4856406 IC50 = 6330.0 nM 5.20
CHEMBL4878601 IC50 = 11900.0 nM 4.92
CHEMBL4873971 IC50 = 58200.0 nM 4.24