Assay Detail
Binding
CHEMBL4823342
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in baculovirus infected insect cells using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after 90 mins by fluorimetry
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synergistic induction of apoptosis in resistant head and neck carcinoma and leukemia by alkoxyamide-based histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.50 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4876405 | — | — | 1 | 7.96 |
| CHEMBL4850081 | — | — | 1 | 7.89 |
| CHEMBL4875953 | — | — | 1 | 7.75 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.62 |
| CHEMBL4866536 | — | — | 1 | 7.60 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 6.93 |
| CHEMBL4870868 | — | — | 1 | 6.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4876405 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4850081 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4875953 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4866536 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL4870868 | — | IC50 | = | 173.0 | nM | 6.76 |