Assay Detail
Binding
CHEMBL4823358
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Class 1/2b HDAC in human HL-60 cells by HDAC-Glo assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synergistic induction of apoptosis in resistant head and neck carcinoma and leukemia by alkoxyamide-based histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.80 | 7.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4866536 | — | — | 1 | 7.13 |
| CHEMBL4870868 | — | — | 1 | 7.07 |
| CHEMBL511749 | — | — | 1 | 6.96 |
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4866536 | — | IC50 | = | 73.2 | nM | 7.13 |
| CHEMBL4870868 | — | IC50 | = | 85.1 | nM | 7.07 |
| CHEMBL511749 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL2364628 | RICOLINOSTAT | IC50 | = | 902.0 | nM | 6.04 |