Assay Detail
Functional
CHEMBL4823679
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Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.74 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4858291 | — | — | 1 | 10.22 |
| CHEMBL4871539 | — | — | 1 | 9.68 |
| CHEMBL4060033 | — | — | 1 | 9.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4858291 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL4871539 | — | IC50 | = | 0.207 | nM | 9.68 |
| CHEMBL4060033 | — | IC50 | = | 0.475 | nM | 9.32 |