Assay Detail
Binding
CHEMBL4823680
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human SHP2 catalytic activity in human MV4-11 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 11 (CHEMBL3864) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 10.10 | 10.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4858291 | — | — | 1 | 10.77 |
| CHEMBL4060033 | — | — | 1 | 9.84 |
| CHEMBL4871539 | — | — | 1 | 9.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4858291 | — | IC50 | = | 0.017 | nM | 10.77 |
| CHEMBL4060033 | — | IC50 | = | 0.145 | nM | 9.84 |
| CHEMBL4871539 | — | IC50 | = | 0.202 | nM | 9.70 |