Assay Detail
Binding
CHEMBL4823881
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Inhibition of full length recombinant human HDAC6 expressed in baculovirus infected Sf9 insect cells using RHKKAc fluorogenic peptide as substrate preincubated for 5 to 10 mins followed by substrate addition and measured after 2 hrs by fluorescence assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.32 | 7.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.78 |
| CHEMBL4865650 | — | — | 1 | 5.73 |
| CHEMBL2179618 | NEXTURASTAT A | — | 1 | 5.66 |
| CHEMBL4852645 | — | — | 1 | 5.58 |
| CHEMBL4846263 | — | — | 1 | 5.49 |
| CHEMBL4536605 | — | — | 1 | 5.28 |
| CHEMBL4852043 | — | — | 1 | 5.28 |
| CHEMBL4856047 | — | — | 1 | 5.07 |
| CHEMBL4846892 | — | — | 1 | 4.98 |
| CHEMBL4856805 | — | — | 1 | 4.85 |
| CHEMBL4871846 | — | — | 1 | 4.71 |
| CHEMBL4873780 | — | — | 1 | 4.71 |
| CHEMBL4871991 | — | — | 1 | 4.68 |
| CHEMBL4849440 | — | — | 1 | 4.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 16.8 | nM | 7.78 |
| CHEMBL4865650 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL2179618 | NEXTURASTAT A | IC50 | = | 2186.0 | nM | 5.66 |
| CHEMBL4852645 | — | IC50 | = | 2620.0 | nM | 5.58 |
| CHEMBL4846263 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL4536605 | — | IC50 | = | 5230.0 | nM | 5.28 |
| CHEMBL4852043 | — | IC50 | = | 5240.0 | nM | 5.28 |
| CHEMBL4856047 | — | IC50 | = | 8430.0 | nM | 5.07 |
| CHEMBL4846892 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL4856805 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL4871846 | — | IC50 | = | 19550.0 | nM | 4.71 |
| CHEMBL4873780 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL4871991 | — | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL4849440 | — | IC50 | = | 21200.0 | nM | 4.67 |