Assay Detail
Binding
CHEMBL4823888
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human HDAC6 using Ac-GAK(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence-based assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 8.65 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4863515 | — | — | 1 | 9.52 |
| CHEMBL4536605 | — | — | 1 | 9.30 |
| CHEMBL4846435 | — | — | 1 | 9.15 |
| CHEMBL4846714 | — | — | 1 | 9.10 |
| CHEMBL4857825 | — | — | 1 | 9.05 |
| CHEMBL4856735 | — | — | 1 | 9.00 |
| CHEMBL4874875 | — | — | 1 | 8.89 |
| CHEMBL2179618 | NEXTURASTAT A | — | 1 | 8.80 |
| CHEMBL4847663 | — | — | 1 | 8.62 |
| CHEMBL4847122 | — | — | 1 | 8.57 |
| CHEMBL4859648 | — | — | 1 | 8.54 |
| CHEMBL4856920 | — | — | 1 | 8.34 |
| CHEMBL4847454 | — | — | 1 | 8.30 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 8.17 |
| CHEMBL4856207 | — | — | 1 | 8.05 |
| CHEMBL4873778 | — | — | 1 | 7.92 |
| CHEMBL4866436 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4863515 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4536605 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4846435 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4846714 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4857825 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4856735 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4874875 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL2179618 | NEXTURASTAT A | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4847663 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4847122 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4859648 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4856920 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL4847454 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL4856207 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4873778 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4866436 | — | IC50 | = | 17.0 | nM | 7.77 |