Assay Detail
Binding
CHEMBL4823889
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Inhibition of recombinant human HDAC1 using Ac-GAK(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence-based assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.54 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.51 |
| CHEMBL4857825 | — | — | 1 | 6.97 |
| CHEMBL4847122 | — | — | 1 | 6.93 |
| CHEMBL4846714 | — | — | 1 | 6.90 |
| CHEMBL4874875 | — | — | 1 | 6.85 |
| CHEMBL2179618 | NEXTURASTAT A | — | 1 | 6.82 |
| CHEMBL4847663 | — | — | 1 | 6.82 |
| CHEMBL4863515 | — | — | 1 | 6.74 |
| CHEMBL4856920 | — | — | 1 | 6.61 |
| CHEMBL4859648 | — | — | 1 | 6.56 |
| CHEMBL4873778 | — | — | 1 | 6.51 |
| CHEMBL4846435 | — | — | 1 | 6.45 |
| CHEMBL4536605 | — | — | 1 | 6.11 |
| CHEMBL4866436 | — | — | 1 | 5.97 |
| CHEMBL4847454 | — | — | 1 | 5.88 |
| CHEMBL4856207 | — | — | 1 | 5.80 |
| CHEMBL4856735 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4857825 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL4847122 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL4846714 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL4874875 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL2179618 | NEXTURASTAT A | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL4847663 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4863515 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL4856920 | — | IC50 | = | 248.0 | nM | 6.61 |
| CHEMBL4859648 | — | IC50 | = | 276.0 | nM | 6.56 |
| CHEMBL4873778 | — | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL4846435 | — | IC50 | = | 356.0 | nM | 6.45 |
| CHEMBL4536605 | — | IC50 | = | 769.0 | nM | 6.11 |
| CHEMBL4866436 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4847454 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL4856207 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL4856735 | — | IC50 | = | 1900.0 | nM | 5.72 |