Assay Detail
Binding
CHEMBL4823905
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Nanoluc-fused HDAC6 CD2 (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NANOBRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.64 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4536605 | — | — | 1 | 7.22 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.85 |
| CHEMBL4846435 | — | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4536605 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4846435 | — | IC50 | = | 1370.0 | nM | 5.86 |