Assay Detail
Binding
CHEMBL4823906
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC6 in human RPMI-8226 cells assessed as increase in tubulin acetylation incubated for 6 hrs by Western blot analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.54 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4846435 | — | — | 1 | 6.85 |
| CHEMBL4536605 | — | — | 1 | 6.80 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4846435 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4536605 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2018302 | TUBASTATIN A | EC50 | = | 1090.0 | nM | 5.96 |