Assay Detail
Binding
CHEMBL4823989
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of RSV RNP complex transcription incubated for 90 mins by agarose gel electrophoresis assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Respiratory syncytial virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine <i>C</i>-Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.43 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2016757 | GS-441524 | 1.0 | 1 | 5.96 |
| CHEMBL2016758 | — | — | 1 | 5.82 |
| CHEMBL2016760 | — | — | 1 | 5.52 |
| CHEMBL3120779 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2016757 | GS-441524 | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2016758 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2016760 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3120779 | — | IC50 | = | 38000.0 | nM | 4.42 |