Assay Detail
Functional
CHEMBL4823993
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HCV 1b infected in human Huh-7 cells assessed as reduction in viral replication measured after 3 days by dual-Glo luciferase assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine <i>C</i>-Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.09 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4079082 | — | — | 1 | 8.46 |
| CHEMBL2016757 | GS-441524 | 1.0 | 1 | 5.39 |
| CHEMBL2016758 | — | — | 1 | 4.41 |
| CHEMBL2016760 | — | — | 1 | - |
| CHEMBL3120779 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4079082 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL2016757 | GS-441524 | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL2016758 | — | EC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL2016760 | — | EC50 | > | 89000.0 | nM | - |
| CHEMBL3120779 | — | EC50 | > | 89000.0 | nM | - |