Assay Detail
Functional
CHEMBL4824283
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Cytotoxicity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel cabazitaxel analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.92 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4875542 | — | — | 1 | 8.30 |
| CHEMBL4871697 | — | — | 1 | 8.10 |
| CHEMBL4874745 | — | — | 1 | 8.10 |
| CHEMBL4868149 | — | — | 1 | 8.10 |
| CHEMBL4860277 | — | — | 1 | 8.10 |
| CHEMBL4863827 | — | — | 1 | 7.96 |
| CHEMBL4850010 | — | — | 1 | 7.92 |
| CHEMBL4867861 | — | — | 1 | 7.82 |
| CHEMBL1201748 | CABAZITAXEL | 4.0 | 1 | 7.82 |
| CHEMBL4850932 | — | — | 1 | 7.77 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | 4.0 | 1 | 7.71 |
| CHEMBL4863640 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4875542 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4871697 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4874745 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4868149 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4860277 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4863827 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4850010 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4867861 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1201748 | CABAZITAXEL | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4850932 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL4863640 | — | IC50 | = | 53.0 | nM | 7.28 |