Assay Detail
Functional
CHEMBL4824288
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Cytotoxicity against human KB/VCR cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB/VCR |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel cabazitaxel analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.59 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4860277 | — | — | 1 | 7.51 |
| CHEMBL4863827 | — | — | 1 | 7.11 |
| CHEMBL1201748 | CABAZITAXEL | 4.0 | 1 | 6.81 |
| CHEMBL4850932 | — | — | 1 | 6.64 |
| CHEMBL4868149 | — | — | 1 | 6.60 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | 4.0 | 1 | 6.58 |
| CHEMBL4875542 | — | — | 1 | 6.50 |
| CHEMBL4850010 | — | — | 1 | 6.50 |
| CHEMBL4871697 | — | — | 1 | 6.29 |
| CHEMBL4867861 | — | — | 1 | 6.04 |
| CHEMBL4874745 | — | — | 1 | 5.91 |
| CHEMBL4863640 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4860277 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4863827 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL1201748 | CABAZITAXEL | IC50 | = | 155.5 | nM | 6.81 |
| CHEMBL4850932 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL4868149 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | IC50 | = | 265.7 | nM | 6.58 |
| CHEMBL4875542 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4850010 | — | IC50 | = | 315.0 | nM | 6.50 |
| CHEMBL4871697 | — | IC50 | = | 515.0 | nM | 6.29 |
| CHEMBL4867861 | — | IC50 | = | 911.0 | nM | 6.04 |
| CHEMBL4874745 | — | IC50 | = | 1221.0 | nM | 5.91 |
| CHEMBL4863640 | — | IC50 | > | 2500.0 | nM | - |