Assay Detail
Binding
CHEMBL4824404
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Inhibition of Bordetella pertussis ACT by cell free assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bordetella pertussis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Acyclic nucleoside phosphonates with 2-aminothiazole base as inhibitors of bacterial and mammalian adenylate cyclases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.67 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1162433 | ADEFOVIR DIPHOSPHATE | -1.0 | 1 | 7.75 |
| CHEMBL4848421 | — | — | 1 | 7.43 |
| CHEMBL4852594 | — | — | 1 | 6.74 |
| CHEMBL4855382 | — | — | 1 | 6.73 |
| CHEMBL4853492 | — | — | 1 | 6.72 |
| CHEMBL4858677 | — | — | 1 | 6.50 |
| CHEMBL4852011 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1162433 | ADEFOVIR DIPHOSPHATE | IC50 | = | 17.8 | nM | 7.75 |
| CHEMBL4848421 | — | IC50 | = | 37.4 | nM | 7.43 |
| CHEMBL4852594 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL4855382 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL4853492 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL4858677 | — | IC50 | = | 313.0 | nM | 6.50 |
| CHEMBL4852011 | — | IC50 | = | 15960.0 | nM | 4.80 |