Assay Detail
Binding
CHEMBL4824591
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Inhibition of human cytomegalovirus pUL89 endonuclease activity using 60 bp dsDNA substrate incubated for 30 mins by ELISA-based biochemical assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human betaherpesvirus 5 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tripartite terminase subunit 3 (CHEMBL4879551) ↗| Type | SINGLE PROTEIN |
| Organism | Human cytomegalovirus |
Publication
Metal binding 6-arylthio-3-hydroxypyrimidine-2,4-diones inhibited human cytomegalovirus by targeting the pUL89 endonuclease of the terminase complex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 4.96 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4284648 | — | — | 1 | 5.72 |
| CHEMBL4445181 | — | — | 1 | 5.48 |
| CHEMBL4854031 | — | — | 1 | 5.46 |
| CHEMBL4863466 | — | — | 1 | 5.46 |
| CHEMBL4280139 | — | — | 1 | 5.44 |
| CHEMBL4877189 | — | — | 1 | 5.24 |
| CHEMBL4875949 | — | — | 1 | 5.24 |
| CHEMBL4848335 | — | — | 1 | 5.21 |
| CHEMBL4858935 | — | — | 1 | 5.19 |
| CHEMBL4863972 | — | — | 1 | 5.17 |
| CHEMBL4876554 | — | — | 1 | 5.09 |
| CHEMBL4865046 | — | — | 1 | 4.93 |
| CHEMBL4851918 | — | — | 1 | 4.92 |
| CHEMBL4869344 | — | — | 1 | 4.90 |
| CHEMBL4866913 | — | — | 1 | 4.85 |
| CHEMBL4277935 | — | — | 1 | 4.66 |
| CHEMBL4851259 | — | — | 1 | 4.64 |
| CHEMBL4868395 | — | — | 1 | 4.64 |
| CHEMBL4870892 | — | — | 1 | 4.62 |
| CHEMBL4852175 | — | — | 1 | 4.58 |
| CHEMBL4286262 | — | — | 1 | 4.50 |
| CHEMBL4285791 | — | — | 1 | 4.47 |
| CHEMBL4846657 | — | — | 1 | 4.37 |
| CHEMBL4861759 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4284648 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4445181 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4854031 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4863466 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4280139 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4877189 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4875949 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4848335 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4858935 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4863972 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4876554 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL4865046 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL4851918 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4869344 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL4866913 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL4277935 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4851259 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL4868395 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL4870892 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4852175 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL4286262 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL4285791 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL4846657 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL4861759 | — | IC50 | = | 48000.0 | nM | 4.32 |