Assay Detail
Binding
CHEMBL4824876
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Inhibition of IDO1 in IFNgamma-stimulated human HeLa cells preincubated for 2 hrs followed by recombinant human IFNgamma stimulation and measured after 18 hrs by fluorescence based microplate reader assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Conformational-Analysis-Guided Discovery of 2,3-Disubstituted Pyridine IDO1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.97 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4786690 | — | — | 1 | 8.70 |
| CHEMBL4868709 | — | — | 1 | 8.70 |
| CHEMBL4845988 | — | — | 1 | 8.70 |
| CHEMBL4848094 | — | — | 1 | 8.70 |
| CHEMBL4851220 | — | — | 1 | 8.70 |
| CHEMBL4860353 | — | — | 1 | 8.52 |
| CHEMBL4877466 | — | — | 1 | 8.40 |
| CHEMBL4859400 | — | — | 1 | 8.30 |
| CHEMBL4861763 | — | — | 1 | 8.15 |
| CHEMBL4859579 | — | — | 1 | 7.92 |
| CHEMBL4860098 | — | — | 1 | 7.85 |
| CHEMBL4849714 | — | — | 1 | 7.72 |
| CHEMBL4860594 | — | — | 1 | 7.58 |
| CHEMBL4847982 | — | — | 1 | 7.40 |
| CHEMBL4849654 | — | — | 1 | 7.37 |
| CHEMBL4857086 | — | — | 1 | 7.32 |
| CHEMBL4854619 | — | — | 1 | 7.10 |
| CHEMBL4873558 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4786690 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4868709 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4845988 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4848094 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4851220 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4860353 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4877466 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4859400 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4861763 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4859579 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4860098 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4849714 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4860594 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4847982 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4849654 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4857086 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4854619 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4873558 | — | IC50 | = | 475.0 | nM | 6.32 |