Assay Detail
Binding
CHEMBL4824877
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Inhibition of IDO1 in IFNgamma-stimulated mouse M109 cells preincubated for 2 hrs followed by recombinant murine IFNgamma stimulation and measured after 18 hrs by fluorescence based microplate reader assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | M109 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Conformational-Analysis-Guided Discovery of 2,3-Disubstituted Pyridine IDO1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.70 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4786690 | — | — | 1 | 8.70 |
| CHEMBL4861763 | — | — | 1 | 8.52 |
| CHEMBL4859400 | — | — | 1 | 8.52 |
| CHEMBL4845988 | — | — | 1 | 8.22 |
| CHEMBL4877466 | — | — | 1 | 8.22 |
| CHEMBL4868709 | — | — | 1 | 8.15 |
| CHEMBL4851220 | — | — | 1 | 7.96 |
| CHEMBL4848094 | — | — | 1 | 7.85 |
| CHEMBL4859579 | — | — | 1 | 7.80 |
| CHEMBL4860353 | — | — | 1 | 7.66 |
| CHEMBL4849714 | — | — | 1 | 7.51 |
| CHEMBL4847982 | — | — | 1 | 7.40 |
| CHEMBL4860098 | — | — | 1 | 7.12 |
| CHEMBL4860594 | — | — | 1 | 7.01 |
| CHEMBL4857086 | — | — | 1 | 6.92 |
| CHEMBL4854619 | — | — | 1 | 6.71 |
| CHEMBL4849654 | — | — | 1 | 6.71 |
| CHEMBL4873558 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4786690 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4861763 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4859400 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4845988 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4877466 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4868709 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4851220 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4848094 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4859579 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4860353 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4849714 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4847982 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4860098 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL4860594 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL4857086 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL4854619 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL4849654 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL4873558 | — | IC50 | > | 1000.0 | nM | - |