Assay Detail
Binding
CHEMBL4824940
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PU-H71-FITC3 binding to recombinant N-terminal HSP90alpha (unknown origin) incubated for 2 hrs by fluorescence polarization assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.00 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200102 | PU-H71 | 2.0 | 1 | 7.14 |
| CHEMBL4869481 | — | — | 1 | 6.41 |
| CHEMBL4068596 | — | — | 1 | 6.37 |
| CHEMBL4863672 | — | — | 1 | 6.27 |
| CHEMBL4853988 | — | — | 1 | 6.11 |
| CHEMBL4850126 | — | — | 1 | 6.05 |
| CHEMBL4870087 | — | — | 1 | 5.96 |
| CHEMBL4866705 | — | — | 1 | 5.95 |
| CHEMBL4863988 | — | — | 1 | 5.90 |
| CHEMBL4870579 | — | — | 1 | 5.73 |
| CHEMBL4854861 | — | — | 1 | 5.71 |
| CHEMBL4867384 | — | — | 1 | 5.52 |
| CHEMBL4857569 | — | — | 1 | 5.48 |
| CHEMBL4846028 | — | — | 1 | 5.35 |
| CHEMBL4879021 | — | — | 1 | - |
| CHEMBL4846176 | — | — | 1 | - |
| CHEMBL4864235 | — | — | 1 | - |
| CHEMBL4853048 | — | — | 1 | - |
| CHEMBL4876733 | — | — | 1 | - |
| CHEMBL4864922 | — | — | 1 | - |
| CHEMBL4860652 | — | — | 1 | - |
| CHEMBL4876871 | — | — | 1 | - |
| CHEMBL4865186 | — | — | 1 | - |
| CHEMBL4872173 | — | — | 1 | - |
| CHEMBL4874124 | — | — | 1 | - |
| CHEMBL4859919 | — | — | 1 | - |
| CHEMBL4866835 | — | — | 1 | - |
| CHEMBL4871630 | — | — | 1 | - |
| CHEMBL4870963 | — | — | 1 | - |
| CHEMBL4866958 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200102 | PU-H71 | IC50 | = | 72.9 | nM | 7.14 |
| CHEMBL4869481 | — | IC50 | = | 394.0 | nM | 6.41 |
| CHEMBL4068596 | — | IC50 | = | 431.0 | nM | 6.37 |
| CHEMBL4863672 | — | IC50 | = | 541.0 | nM | 6.27 |
| CHEMBL4853988 | — | IC50 | = | 778.0 | nM | 6.11 |
| CHEMBL4850126 | — | IC50 | = | 893.0 | nM | 6.05 |
| CHEMBL4870087 | — | IC50 | = | 1097.0 | nM | 5.96 |
| CHEMBL4866705 | — | IC50 | = | 1134.0 | nM | 5.95 |
| CHEMBL4863988 | — | IC50 | = | 1247.0 | nM | 5.90 |
| CHEMBL4870579 | — | IC50 | = | 1862.0 | nM | 5.73 |
| CHEMBL4854861 | — | IC50 | = | 1965.0 | nM | 5.71 |
| CHEMBL4867384 | — | IC50 | = | 2996.0 | nM | 5.52 |
| CHEMBL4857569 | — | IC50 | = | 3312.0 | nM | 5.48 |
| CHEMBL4846028 | — | IC50 | = | 4494.0 | nM | 5.35 |
| CHEMBL4870476 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4879021 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4846176 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4864235 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4853048 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4876733 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4864922 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4860652 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4876871 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4865186 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4872173 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4874124 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4859919 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4866835 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4871630 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4870963 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4866958 | — | IC50 | > | 5000.0 | nM | - |