Assay Detail
Functional
CHEMBL4825150
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Antiviral activity against pseudovirus SARS-CoV-2 spike protein infected in HEK293 cells expressing ACE2 assessed as reduction in pseudotyped particle entry incubated for 48 hrs incubation by luminescence assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Discovery of Small Molecule Entry Inhibitors Targeting the Fusion Peptide of SARS-CoV-2 Spike Protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.76 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3084665 | — | — | 1 | 5.16 |
| CHEMBL4859986 | — | — | 1 | 5.05 |
| CHEMBL4874417 | — | — | 1 | 4.90 |
| CHEMBL1200795 | CLEMASTINE FUMARATE | 4.0 | 1 | 4.85 |
| CHEMBL1683848 | — | — | 1 | 4.80 |
| CHEMBL4862613 | — | — | 1 | 4.80 |
| CHEMBL4877865 | — | — | 1 | 4.80 |
| CHEMBL4851921 | — | — | 1 | 4.65 |
| CHEMBL1530148 | — | — | 1 | 4.65 |
| CHEMBL1200383 | BENZTROPINE MESYLATE | 4.0 | 1 | 4.55 |
| CHEMBL4846537 | — | — | 1 | 4.50 |
| CHEMBL4872159 | — | — | 1 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3084665 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4859986 | — | IC50 | = | 8910.0 | nM | 5.05 |
| CHEMBL4874417 | — | IC50 | = | 12590.0 | nM | 4.90 |
| CHEMBL1200795 | CLEMASTINE FUMARATE | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL1683848 | — | IC50 | = | 15850.0 | nM | 4.80 |
| CHEMBL4862613 | — | IC50 | = | 15850.0 | nM | 4.80 |
| CHEMBL4877865 | — | IC50 | = | 15850.0 | nM | 4.80 |
| CHEMBL4851921 | — | IC50 | = | 22390.0 | nM | 4.65 |
| CHEMBL1530148 | — | IC50 | = | 22390.0 | nM | 4.65 |
| CHEMBL1200383 | BENZTROPINE MESYLATE | IC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL4846537 | — | IC50 | = | 31620.0 | nM | 4.50 |
| CHEMBL4872159 | — | IC50 | = | 35460.0 | nM | 4.45 |