Assay Detail
Functional
CHEMBL4825152
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against VSV-G enveloped pseudovirus assessed as inhibition of viral entry by pseudotyped particle entry assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Vesicular stomatitis virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Vesicular stomatitis virus (CHEMBL613739) ↗| Type | ORGANISM |
| Organism | Vesicular stomatitis virus |
Publication
Discovery of Small Molecule Entry Inhibitors Targeting the Fusion Peptide of SARS-CoV-2 Spike Protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.57 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4859986 | — | — | 1 | 5.10 |
| CHEMBL4874417 | — | — | 1 | 4.45 |
| CHEMBL4872159 | — | — | 1 | 4.40 |
| CHEMBL3084665 | — | — | 1 | 4.31 |
| CHEMBL1683848 | — | — | 1 | - |
| CHEMBL4862613 | — | — | 1 | - |
| CHEMBL4851921 | — | — | 1 | - |
| CHEMBL4877865 | — | — | 1 | - |
| CHEMBL1530148 | — | — | 1 | - |
| CHEMBL4846537 | — | — | 1 | - |
| CHEMBL1200383 | BENZTROPINE MESYLATE | 4.0 | 1 | - |
| CHEMBL1200795 | CLEMASTINE FUMARATE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4859986 | — | IC50 | = | 7940.0 | nM | 5.10 |
| CHEMBL4874417 | — | IC50 | = | 35480.0 | nM | 4.45 |
| CHEMBL4872159 | — | IC50 | = | 39810.0 | nM | 4.40 |
| CHEMBL3084665 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL1683848 | — | IC50 | > | 57500.0 | nM | - |
| CHEMBL4862613 | — | IC50 | > | 57500.0 | nM | - |
| CHEMBL4851921 | — | IC50 | > | 57500.0 | nM | - |
| CHEMBL4877865 | — | IC50 | > | 57500.0 | nM | - |
| CHEMBL1530148 | — | IC50 | > | 57500.0 | nM | - |
| CHEMBL4846537 | — | IC50 | > | 57500.0 | nM | - |
| CHEMBL1200383 | BENZTROPINE MESYLATE | IC50 | - | — | - | |
| CHEMBL1200795 | CLEMASTINE FUMARATE | IC50 | - | — | - |