Assay Detail
Functional
CHEMBL4825154
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Antiviral activity against SARS COV-2 infected in African green monkey Vero E6 cells expressing human ACE2 assessed as reduction in virus-induced cytopathic effect measured after 72 hrs by cell titer glo-based luminescence assay
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero E6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Discovery of Small Molecule Entry Inhibitors Targeting the Fusion Peptide of SARS-CoV-2 Spike Protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.02 | 5.35 |
| Efficacy | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4874417 | — | — | 1 | 5.35 |
| CHEMBL4859986 | — | — | 1 | 5.10 |
| CHEMBL4862613 | — | — | 1 | 5.10 |
| CHEMBL4877865 | — | — | 1 | 5.10 |
| CHEMBL1200795 | CLEMASTINE FUMARATE | 4.0 | 1 | 5.10 |
| CHEMBL3084665 | — | — | 1 | 4.99 |
| CHEMBL4872159 | — | — | 1 | 4.90 |
| CHEMBL4846537 | — | — | 1 | 4.89 |
| CHEMBL4851921 | — | — | 1 | 4.85 |
| CHEMBL1200383 | BENZTROPINE MESYLATE | 4.0 | 1 | 4.85 |
| CHEMBL1683848 | — | — | 1 | - |
| CHEMBL1530148 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4874417 | — | IC50 | = | 4470.0 | nM | 5.35 |
| CHEMBL4859986 | — | IC50 | = | 7940.0 | nM | 5.10 |
| CHEMBL4862613 | — | IC50 | = | 7940.0 | nM | 5.10 |
| CHEMBL4877865 | — | IC50 | = | 7940.0 | nM | 5.10 |
| CHEMBL1200795 | CLEMASTINE FUMARATE | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL3084665 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4872159 | — | IC50 | = | 12590.0 | nM | 4.90 |
| CHEMBL4846537 | — | IC50 | = | 12950.0 | nM | 4.89 |
| CHEMBL4851921 | — | IC50 | = | 14130.0 | nM | 4.85 |
| CHEMBL1200383 | BENZTROPINE MESYLATE | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL1683848 | — | Efficacy | = | 7.94 | uM | - |
| CHEMBL1530148 | — | IC50 | > | 20000.0 | nM | - |