Assay Detail
Functional
CHEMBL4825159
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against pseudovirus SARS-CoV-2 spike glycoprotein infected human Huh-7 cells assessed as inhibition of viral infection measured after 24 hrs by luciferase reporter gene assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Discovery of Small Molecule Entry Inhibitors Targeting the Fusion Peptide of SARS-CoV-2 Spike Protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.54 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4859986 | — | — | 1 | 5.80 |
| CHEMBL4862613 | — | — | 1 | 5.77 |
| CHEMBL4851921 | — | — | 1 | 5.77 |
| CHEMBL1200795 | CLEMASTINE FUMARATE | 4.0 | 1 | 5.65 |
| CHEMBL1683848 | — | — | 1 | 5.49 |
| CHEMBL3084665 | — | — | 1 | 5.27 |
| CHEMBL1200383 | BENZTROPINE MESYLATE | 4.0 | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4859986 | — | IC50 | = | 1572.0 | nM | 5.80 |
| CHEMBL4862613 | — | IC50 | = | 1696.0 | nM | 5.77 |
| CHEMBL4851921 | — | IC50 | = | 1681.0 | nM | 5.77 |
| CHEMBL1200795 | CLEMASTINE FUMARATE | IC50 | = | 2245.0 | nM | 5.65 |
| CHEMBL1683848 | — | IC50 | = | 3273.0 | nM | 5.49 |
| CHEMBL3084665 | — | IC50 | = | 5406.0 | nM | 5.27 |
| CHEMBL1200383 | BENZTROPINE MESYLATE | IC50 | = | 9662.0 | nM | 5.01 |