Assay Detail
Binding
CHEMBL4825196
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Inhibition of human ALDH1A1 assessed as NADH formation using propionaldehyde as substrate by spectrophotometry
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of benzimidazole derivatives as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.00 | 6.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4871242 | — | — | 1 | 6.61 |
| CHEMBL4847630 | — | — | 1 | 6.34 |
| CHEMBL4854627 | — | — | 1 | 6.20 |
| CHEMBL4862473 | — | — | 1 | 6.04 |
| CHEMBL4855040 | — | — | 1 | 5.99 |
| CHEMBL4845791 | — | — | 1 | 5.82 |
| CHEMBL4871374 | — | — | 1 | 5.68 |
| CHEMBL3416562 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4871242 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL4847630 | — | IC50 | = | 458.0 | nM | 6.34 |
| CHEMBL4854627 | — | IC50 | = | 626.0 | nM | 6.20 |
| CHEMBL4862473 | — | IC50 | = | 921.0 | nM | 6.04 |
| CHEMBL4855040 | — | IC50 | = | 1023.0 | nM | 5.99 |
| CHEMBL4845791 | — | IC50 | = | 1498.0 | nM | 5.82 |
| CHEMBL4871374 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL3416562 | — | IC50 | = | 4600.0 | nM | 5.34 |