Assay Detail
Functional
CHEMBL4825215
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Antiviral activity against SARS-CoV-2 infected in 16HBE14o- cells assessed as inhibition of viral replication after 1 day by Nano-Glo luciferase assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | 16HBE14o- |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 6.05 | 6.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4861071 | — | — | 1 | 6.76 |
| CHEMBL4870541 | — | — | 1 | 6.28 |
| CHEMBL4065616 | REMDESIVIR | 4.0 | 1 | 6.23 |
| CHEMBL4869872 | — | — | 1 | 6.14 |
| CHEMBL4872510 | — | — | 1 | 6.09 |
| CHEMBL4862027 | — | — | 1 | 5.97 |
| CHEMBL4854695 | — | — | 1 | 5.92 |
| CHEMBL4853536 | — | — | 1 | 5.82 |
| CHEMBL4854767 | — | — | 1 | 5.75 |
| CHEMBL4867191 | — | — | 1 | 5.50 |
| CHEMBL4863809 | — | — | 1 | - |
| CHEMBL4873590 | — | — | 1 | - |
| CHEMBL4873122 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4861071 | — | EC50 | = | 175.0 | nM | 6.76 |
| CHEMBL4870541 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4065616 | REMDESIVIR | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL4869872 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL4872510 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4862027 | — | EC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4854695 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4853536 | — | EC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL4854767 | — | EC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL4867191 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4863809 | — | EC50 | > | 40000.0 | nM | - |
| CHEMBL4873590 | — | EC50 | - | — | - | |
| CHEMBL4873122 | — | EC50 | - | — | - |