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Assay Detail

CHEMBL4825241

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human partial length BRPF1 (E627 to G740 residues) expressed in bacterial expression system by BROMOscan assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Peregrin (CHEMBL3132741)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Optimization of Naphthyridones into Selective TATA-Binding Protein Associated Factor 1 (TAF1) Bromodomain Inhibitors.
Clegg MA, Theodoulou NH, Bamborough P, Chung CW, Craggs PD, Demont EH, Gordon LJ, Liwicki GM, Phillipou A, Tomkinson NCO, Prinjha RK, Humphreys PG.
ACS Med Chem Lett (2021) 12 : 1308 -1317
PubMed 34413961 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 5.30 5.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4864027 1 5.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4864027 Ki = 5011.87 nM 5.30