Assay Detail
Functional
CHEMBL4825275
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B16-F10 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel acridine and quinoline derivatives as tubulin polymerization inhibitors with anticancer activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 5.11 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 7.85 |
| CHEMBL4873690 | — | — | 1 | 6.25 |
| CHEMBL4868276 | — | — | 1 | 5.89 |
| CHEMBL4879075 | — | — | 1 | 5.86 |
| CHEMBL4855855 | — | — | 1 | 5.86 |
| CHEMBL52101 | — | — | 1 | 5.67 |
| CHEMBL4856763 | — | — | 1 | 5.61 |
| CHEMBL4865037 | — | — | 1 | 5.42 |
| CHEMBL4866096 | — | — | 1 | 5.39 |
| CHEMBL4865322 | — | — | 1 | 5.34 |
| CHEMBL4848240 | — | — | 1 | 5.33 |
| CHEMBL4875069 | — | — | 1 | 5.33 |
| CHEMBL586902 | — | — | 1 | 5.30 |
| CHEMBL4871889 | — | — | 1 | 5.24 |
| CHEMBL4858559 | — | — | 1 | 5.19 |
| CHEMBL1587558 | — | — | 1 | 5.18 |
| CHEMBL4863629 | — | — | 1 | 5.18 |
| CHEMBL4872221 | — | — | 1 | 5.17 |
| CHEMBL1811977 | — | — | 1 | 5.16 |
| CHEMBL3925728 | — | — | 1 | 5.14 |
| CHEMBL4879267 | — | — | 1 | 5.12 |
| CHEMBL4873673 | — | — | 1 | 5.09 |
| CHEMBL4872202 | — | — | 1 | 5.08 |
| CHEMBL4855994 | — | — | 1 | 5.04 |
| CHEMBL4854211 | — | — | 1 | 5.04 |
| CHEMBL4878867 | — | — | 1 | 5.00 |
| CHEMBL4868421 | — | — | 1 | 4.97 |
| CHEMBL4851870 | — | — | 1 | 4.88 |
| CHEMBL4874465 | — | — | 1 | 4.83 |
| CHEMBL4859846 | — | — | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4873690 | — | IC50 | = | 563.0 | nM | 6.25 |
| CHEMBL4868276 | — | IC50 | = | 1279.0 | nM | 5.89 |
| CHEMBL4879075 | — | IC50 | = | 1394.0 | nM | 5.86 |
| CHEMBL4855855 | — | IC50 | = | 1384.0 | nM | 5.86 |
| CHEMBL52101 | — | IC50 | = | 2135.0 | nM | 5.67 |
| CHEMBL4856763 | — | IC50 | = | 2433.0 | nM | 5.61 |
| CHEMBL4865037 | — | IC50 | = | 3787.0 | nM | 5.42 |
| CHEMBL4866096 | — | IC50 | = | 4058.0 | nM | 5.39 |
| CHEMBL4865322 | — | IC50 | = | 4567.0 | nM | 5.34 |
| CHEMBL4848240 | — | IC50 | = | 4680.0 | nM | 5.33 |
| CHEMBL4875069 | — | IC50 | = | 4663.0 | nM | 5.33 |
| CHEMBL586902 | — | IC50 | = | 4983.0 | nM | 5.30 |
| CHEMBL4871889 | — | IC50 | = | 5781.0 | nM | 5.24 |
| CHEMBL4858559 | — | IC50 | = | 6451.0 | nM | 5.19 |
| CHEMBL1587558 | — | IC50 | = | 6537.0 | nM | 5.18 |
| CHEMBL4863629 | — | IC50 | = | 6584.0 | nM | 5.18 |
| CHEMBL4872221 | — | IC50 | = | 6840.0 | nM | 5.17 |
| CHEMBL1811977 | — | IC50 | = | 6974.0 | nM | 5.16 |
| CHEMBL3925728 | — | IC50 | = | 7218.0 | nM | 5.14 |
| CHEMBL4879267 | — | IC50 | = | 7651.0 | nM | 5.12 |
| CHEMBL4873673 | — | IC50 | = | 8047.0 | nM | 5.09 |
| CHEMBL4872202 | — | IC50 | = | 8319.0 | nM | 5.08 |
| CHEMBL4855994 | — | IC50 | = | 9037.0 | nM | 5.04 |
| CHEMBL4854211 | — | IC50 | = | 9064.0 | nM | 5.04 |
| CHEMBL4878867 | — | IC50 | = | 9997.0 | nM | 5.00 |
| CHEMBL4868421 | — | IC50 | = | 10620.0 | nM | 4.97 |
| CHEMBL4851870 | — | IC50 | = | 13340.0 | nM | 4.88 |
| CHEMBL4874465 | — | IC50 | = | 14650.0 | nM | 4.83 |
| CHEMBL4859846 | — | IC50 | = | 15370.0 | nM | 4.81 |
| CHEMBL4874505 | — | IC50 | = | 15370.0 | nM | 4.81 |
| CHEMBL4854015 | — | IC50 | = | 16650.0 | nM | 4.78 |
| CHEMBL4849949 | — | IC50 | = | 18370.0 | nM | 4.74 |
| CHEMBL4858237 | — | IC50 | = | 18060.0 | nM | 4.74 |
| CHEMBL4868108 | — | IC50 | = | 18950.0 | nM | 4.72 |
| CHEMBL4873764 | — | IC50 | = | 19340.0 | nM | 4.71 |
| CHEMBL4862341 | — | IC50 | = | 20170.0 | nM | 4.70 |
| CHEMBL4876977 | — | IC50 | = | 22510.0 | nM | 4.65 |
| CHEMBL4868080 | — | IC50 | = | 25160.0 | nM | 4.60 |
| CHEMBL4859538 | — | IC50 | = | 25520.0 | nM | 4.59 |
| CHEMBL4850128 | — | IC50 | = | 27060.0 | nM | 4.57 |
| CHEMBL4860244 | — | IC50 | = | 28610.0 | nM | 4.54 |
| CHEMBL4872346 | — | IC50 | = | 29490.0 | nM | 4.53 |
| CHEMBL4875930 | — | IC50 | = | 33070.0 | nM | 4.48 |
| CHEMBL4853277 | — | IC50 | = | 38130.0 | nM | 4.42 |
| CHEMBL4850892 | — | IC50 | = | 40370.0 | nM | 4.39 |