Assay Detail
Functional
CHEMBL4825277
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Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel acridine and quinoline derivatives as tubulin polymerization inhibitors with anticancer activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 5.03 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 7.64 |
| CHEMBL4873690 | — | — | 1 | 5.69 |
| CHEMBL4879075 | — | — | 1 | 5.57 |
| CHEMBL4855855 | — | — | 1 | 5.57 |
| CHEMBL4868276 | — | — | 1 | 5.55 |
| CHEMBL4856763 | — | — | 1 | 5.51 |
| CHEMBL52101 | — | — | 1 | 5.44 |
| CHEMBL4865037 | — | — | 1 | 5.40 |
| CHEMBL4865322 | — | — | 1 | 5.38 |
| CHEMBL4848240 | — | — | 1 | 5.28 |
| CHEMBL4875069 | — | — | 1 | 5.22 |
| CHEMBL4866096 | — | — | 1 | 5.21 |
| CHEMBL4872221 | — | — | 1 | 5.19 |
| CHEMBL4871889 | — | — | 1 | 5.19 |
| CHEMBL1587558 | — | — | 1 | 5.17 |
| CHEMBL586902 | — | — | 1 | 5.14 |
| CHEMBL1811977 | — | — | 1 | 5.09 |
| CHEMBL4863629 | — | — | 1 | 5.08 |
| CHEMBL4854211 | — | — | 1 | 5.07 |
| CHEMBL4872202 | — | — | 1 | 5.06 |
| CHEMBL4858559 | — | — | 1 | 5.06 |
| CHEMBL3925728 | — | — | 1 | 5.06 |
| CHEMBL4873673 | — | — | 1 | 5.05 |
| CHEMBL4879267 | — | — | 1 | 5.03 |
| CHEMBL4855994 | — | — | 1 | 5.01 |
| CHEMBL4878867 | — | — | 1 | 4.97 |
| CHEMBL4868421 | — | — | 1 | 4.87 |
| CHEMBL4876977 | — | — | 1 | 4.85 |
| CHEMBL4859846 | — | — | 1 | 4.79 |
| CHEMBL4868108 | — | — | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4873690 | — | IC50 | = | 2047.0 | nM | 5.69 |
| CHEMBL4855855 | — | IC50 | = | 2671.0 | nM | 5.57 |
| CHEMBL4879075 | — | IC50 | = | 2697.0 | nM | 5.57 |
| CHEMBL4868276 | — | IC50 | = | 2801.0 | nM | 5.55 |
| CHEMBL4856763 | — | IC50 | = | 3062.0 | nM | 5.51 |
| CHEMBL52101 | — | IC50 | = | 3667.0 | nM | 5.44 |
| CHEMBL4865037 | — | IC50 | = | 4009.0 | nM | 5.40 |
| CHEMBL4865322 | — | IC50 | = | 4163.0 | nM | 5.38 |
| CHEMBL4848240 | — | IC50 | = | 5304.0 | nM | 5.28 |
| CHEMBL4875069 | — | IC50 | = | 6079.0 | nM | 5.22 |
| CHEMBL4866096 | — | IC50 | = | 6121.0 | nM | 5.21 |
| CHEMBL4871889 | — | IC50 | = | 6492.0 | nM | 5.19 |
| CHEMBL4872221 | — | IC50 | = | 6473.0 | nM | 5.19 |
| CHEMBL1587558 | — | IC50 | = | 6799.0 | nM | 5.17 |
| CHEMBL586902 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL1811977 | — | IC50 | = | 8073.0 | nM | 5.09 |
| CHEMBL4863629 | — | IC50 | = | 8267.0 | nM | 5.08 |
| CHEMBL4854211 | — | IC50 | = | 8608.0 | nM | 5.07 |
| CHEMBL4872202 | — | IC50 | = | 8788.0 | nM | 5.06 |
| CHEMBL4858559 | — | IC50 | = | 8651.0 | nM | 5.06 |
| CHEMBL3925728 | — | IC50 | = | 8647.0 | nM | 5.06 |
| CHEMBL4873673 | — | IC50 | = | 8954.0 | nM | 5.05 |
| CHEMBL4879267 | — | IC50 | = | 9286.0 | nM | 5.03 |
| CHEMBL4855994 | — | IC50 | = | 9821.0 | nM | 5.01 |
| CHEMBL4878867 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL4868421 | — | IC50 | = | 13620.0 | nM | 4.87 |
| CHEMBL4876977 | — | IC50 | = | 14050.0 | nM | 4.85 |
| CHEMBL4859846 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL4868108 | — | IC50 | = | 16070.0 | nM | 4.79 |
| CHEMBL4851870 | — | IC50 | = | 16150.0 | nM | 4.79 |
| CHEMBL4873764 | — | IC50 | = | 16980.0 | nM | 4.77 |
| CHEMBL4849949 | — | IC50 | = | 16830.0 | nM | 4.77 |
| CHEMBL4874465 | — | IC50 | = | 17320.0 | nM | 4.76 |
| CHEMBL4874505 | — | IC50 | = | 18650.0 | nM | 4.73 |
| CHEMBL4862341 | — | IC50 | = | 19710.0 | nM | 4.71 |
| CHEMBL4854015 | — | IC50 | = | 20970.0 | nM | 4.68 |
| CHEMBL4858237 | — | IC50 | = | 23990.0 | nM | 4.62 |
| CHEMBL4850128 | — | IC50 | = | 29900.0 | nM | 4.52 |
| CHEMBL4860244 | — | IC50 | = | 30720.0 | nM | 4.51 |
| CHEMBL4859538 | — | IC50 | = | 30870.0 | nM | 4.51 |
| CHEMBL4872346 | — | IC50 | = | 32140.0 | nM | 4.49 |
| CHEMBL4868080 | — | IC50 | = | 36480.0 | nM | 4.44 |
| CHEMBL4850892 | — | IC50 | = | 43180.0 | nM | 4.37 |
| CHEMBL4875930 | — | IC50 | = | 42870.0 | nM | 4.37 |
| CHEMBL4853277 | — | IC50 | = | 44920.0 | nM | 4.35 |