Assay Detail
Binding
CHEMBL4825322
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Inhibition of Akt/p70S6K in human MDA-MB-436 cells assessed as inhibition of S6 phosphorylation
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-436 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of 4-aminopyrimidine analogs as highly potent dual P70S6K/Akt inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.63 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4853207 | — | — | 1 | 7.96 |
| CHEMBL3925871 | — | — | 1 | 7.40 |
| CHEMBL3941307 | — | — | 1 | 6.52 |
| CHEMBL3982464 | — | — | 1 | 6.40 |
| CHEMBL3912964 | — | — | 1 | 6.40 |
| CHEMBL3978717 | — | — | 1 | 6.40 |
| CHEMBL3922417 | — | — | 1 | 6.22 |
| CHEMBL3929608 | — | — | 1 | 6.16 |
| CHEMBL3935451 | — | — | 1 | 6.10 |
| CHEMBL3928625 | — | — | 1 | 5.92 |
| CHEMBL3964789 | — | — | 1 | 5.92 |
| CHEMBL3948645 | — | — | 1 | 5.82 |
| CHEMBL3920854 | — | — | 1 | 5.72 |
| CHEMBL3964726 | — | — | 1 | 5.64 |
| CHEMBL3890900 | — | — | 1 | 5.58 |
| CHEMBL3935218 | — | — | 1 | 5.54 |
| CHEMBL3919663 | — | — | 1 | 4.66 |
| CHEMBL3922798 | — | — | 1 | 4.31 |
| CHEMBL3962807 | — | — | 1 | 4.28 |
| CHEMBL3916864 | — | — | 1 | 4.26 |
| CHEMBL3919089 | — | — | 1 | 4.19 |
| CHEMBL3917410 | — | — | 1 | 4.11 |
| CHEMBL3936329 | — | — | 1 | 4.05 |
| CHEMBL3903522 | — | — | 1 | - |
| CHEMBL3916957 | — | — | 1 | - |
| CHEMBL3932445 | — | — | 1 | - |
| CHEMBL3931848 | — | — | 1 | - |
| CHEMBL3911401 | — | — | 1 | - |
| CHEMBL3900512 | — | — | 1 | - |
| CHEMBL3931504 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4853207 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3925871 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3941307 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3982464 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3912964 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3978717 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3922417 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3929608 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3935451 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3928625 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3964789 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3948645 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3920854 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3964726 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3890900 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3935218 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3919663 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL3922798 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL3962807 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL3916864 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL3919089 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL3917410 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL3936329 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL3903522 | — | IC50 | = | 136000.0 | nM | - |
| CHEMBL3916957 | — | IC50 | = | 301000.0 | nM | - |
| CHEMBL3932445 | — | IC50 | - | — | - | |
| CHEMBL3931848 | — | IC50 | = | 126000.0 | nM | - |
| CHEMBL3911401 | — | IC50 | = | 197000.0 | nM | - |
| CHEMBL3900512 | — | IC50 | = | 119000.0 | nM | - |
| CHEMBL3931504 | — | IC50 | = | 111000.0 | nM | - |
| CHEMBL4876889 | — | IC50 | = | 159000.0 | nM | - |
| CHEMBL3949501 | — | IC50 | = | 148000.0 | nM | - |
| CHEMBL3933645 | — | IC50 | = | 161000.0 | nM | - |