Assay Detail
Binding
CHEMBL4825323
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG by patch clamp assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 4-aminopyrimidine analogs as highly potent dual P70S6K/Akt inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.77 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3962807 | — | — | 1 | 6.16 |
| CHEMBL3900512 | — | — | 1 | 6.08 |
| CHEMBL3931504 | — | — | 1 | 6.03 |
| CHEMBL3931848 | — | — | 1 | 5.96 |
| CHEMBL3933645 | — | — | 1 | 5.92 |
| CHEMBL3911401 | — | — | 1 | 5.89 |
| CHEMBL4876889 | — | — | 1 | 5.89 |
| CHEMBL3903522 | — | — | 1 | 5.89 |
| CHEMBL3916957 | — | — | 1 | 5.82 |
| CHEMBL3916864 | — | — | 1 | 5.80 |
| CHEMBL3922798 | — | — | 1 | 5.80 |
| CHEMBL3925871 | — | — | 1 | 5.75 |
| CHEMBL3917410 | — | — | 1 | 5.75 |
| CHEMBL3919089 | — | — | 1 | 5.72 |
| CHEMBL3964726 | — | — | 1 | 5.72 |
| CHEMBL3941307 | — | — | 1 | 5.46 |
| CHEMBL3936329 | — | — | 1 | 5.40 |
| CHEMBL3949501 | — | — | 1 | 4.76 |
| CHEMBL3932445 | — | — | 1 | - |
| CHEMBL3919663 | — | — | 1 | - |
| CHEMBL3912964 | — | — | 1 | - |
| CHEMBL3935451 | — | — | 1 | - |
| CHEMBL3929608 | — | — | 1 | - |
| CHEMBL3978717 | — | — | 1 | - |
| CHEMBL3922417 | — | — | 1 | - |
| CHEMBL3964789 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3962807 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3900512 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL3931504 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL3931848 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3933645 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3911401 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4876889 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3903522 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3916957 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3916864 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3922798 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3925871 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3917410 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3919089 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3964726 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3941307 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3936329 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3949501 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL3932445 | — | IC50 | - | — | - | |
| CHEMBL3919663 | — | IC50 | - | — | - | |
| CHEMBL3912964 | — | IC50 | - | — | - | |
| CHEMBL3935451 | — | IC50 | - | — | - | |
| CHEMBL3929608 | — | IC50 | - | — | - | |
| CHEMBL3978717 | — | IC50 | - | — | - | |
| CHEMBL3922417 | — | IC50 | - | — | - | |
| CHEMBL3964789 | — | IC50 | = | 670000.0 | nM | - |