Assay Detail
ADMET
CHEMBL4825482
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Cytotoxicity against human HUVEC cells assessed as reduction in cell proliferation measured after 72 hrs by CellTiter96 Aqueous One Solution Cell Proliferation Assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structurally Optimized Potent Dual-Targeting NBTI Antibacterials with an Enhanced Bifurcated Halogen-Bonding Propensity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.55 | 4.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4879265 | — | — | 1 | 4.73 |
| CHEMBL4868908 | — | — | 1 | 4.65 |
| CHEMBL4873479 | — | — | 1 | 4.54 |
| CHEMBL4862951 | — | — | 1 | 4.54 |
| CHEMBL4879088 | — | — | 1 | 4.53 |
| CHEMBL4862136 | — | — | 1 | 4.50 |
| CHEMBL4866999 | — | — | 1 | 4.48 |
| CHEMBL4864750 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4879265 | — | IC50 | = | 18470.0 | nM | 4.73 |
| CHEMBL4868908 | — | IC50 | = | 22450.0 | nM | 4.65 |
| CHEMBL4873479 | — | IC50 | = | 28530.0 | nM | 4.54 |
| CHEMBL4862951 | — | IC50 | = | 29020.0 | nM | 4.54 |
| CHEMBL4879088 | — | IC50 | = | 29720.0 | nM | 4.53 |
| CHEMBL4862136 | — | IC50 | = | 31900.0 | nM | 4.50 |
| CHEMBL4866999 | — | IC50 | = | 32850.0 | nM | 4.48 |
| CHEMBL4864750 | — | IC50 | = | 34500.0 | nM | 4.46 |