Assay Detail
Functional
CHEMBL4825484
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against wild type Leishmania donovani promastigotes incubated for 72 hrs by resazurin dye based assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Monocyclic Nitro-heteroaryl Nitrones with Dual Mechanism of Activation: Synthesis and Antileishmanial Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.28 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218650 | DELAMANID | 4.0 | 1 | 8.82 |
| CHEMBL4847822 | — | — | 1 | 6.39 |
| CHEMBL4852509 | — | — | 1 | 6.06 |
| CHEMBL4876294 | — | — | 1 | 6.00 |
| CHEMBL4871887 | — | — | 1 | 5.95 |
| CHEMBL4860087 | — | — | 1 | 5.94 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 5.72 |
| CHEMBL4878658 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218650 | DELAMANID | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4847822 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4852509 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4876294 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4871887 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL4860087 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL290960 | NIFURTIMOX | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL4878658 | — | IC50 | = | 4550.0 | nM | 5.34 |