Assay Detail
Functional
CHEMBL4825489
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against intracellular Leishmania infantum MHOM/MA/67/ITMAP-263 amastigotes infected in BALB/c mouse peritoneal macrophage assessed as reduced parasite growth incubated for 72 hrs by PANOTIC staining based assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania infantum |
| Cell Type | Peritoneal macrophage |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Monocyclic Nitro-heteroaryl Nitrones with Dual Mechanism of Activation: Synthesis and Antileishmanial Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.26 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4852509 | — | — | 1 | 7.72 |
| CHEMBL4860087 | — | — | 1 | 6.77 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 6.30 |
| CHEMBL4876294 | — | — | 1 | 5.35 |
| CHEMBL4847822 | — | — | 1 | 5.14 |
| CHEMBL4870182 | — | — | 1 | - |
| CHEMBL351937 | — | — | 1 | - |
| CHEMBL4872421 | — | — | 1 | - |
| CHEMBL4861994 | — | — | 1 | - |
| CHEMBL554606 | — | — | 1 | - |
| CHEMBL4871887 | — | — | 1 | - |
| CHEMBL4878658 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4852509 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4860087 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4876294 | — | IC50 | = | 4490.0 | nM | 5.35 |
| CHEMBL4847822 | — | IC50 | = | 7180.0 | nM | 5.14 |
| CHEMBL4870182 | — | IC50 | - | — | - | |
| CHEMBL351937 | — | IC50 | - | — | - | |
| CHEMBL4872421 | — | IC50 | - | — | - | |
| CHEMBL4861994 | — | IC50 | - | — | - | |
| CHEMBL554606 | — | IC50 | - | — | - | |
| CHEMBL4871887 | — | IC50 | - | — | - | |
| CHEMBL4878658 | — | IC50 | - | — | - |