Assay Detail
Functional
CHEMBL4825490
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against Leishmania donovani LdBOB derived from MHOM/SD/62/1 S-CL2D promastigotes overexpressing NTR1 incubated for 72 hrs by resazurin dye based assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Monocyclic Nitro-heteroaryl Nitrones with Dual Mechanism of Activation: Synthesis and Antileishmanial Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.77 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4860087 | — | — | 1 | 7.52 |
| CHEMBL4852509 | — | — | 1 | 7.30 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 6.96 |
| CHEMBL4871887 | — | — | 1 | 6.62 |
| CHEMBL4878658 | — | — | 1 | 6.57 |
| CHEMBL4847822 | — | — | 1 | 6.52 |
| CHEMBL4876294 | — | — | 1 | 5.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4860087 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4852509 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL290960 | NIFURTIMOX | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4871887 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4878658 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4847822 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4876294 | — | IC50 | = | 1220.0 | nM | 5.91 |